Cortical Representations of Cognitive Control and Working Memory Are Dependent Yet Non-Interacting

IH Harding; BJ Harrison; M Breakspear; C Pantelis; M Yücel

Journal article

Cortical Representations of Cognitive Control and Working Memory Are Dependent Yet Non-Interacting

IH Harding, BJ Harrison, M Breakspear, C Pantelis, M Yücel

Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2016

DOI: 10.1093/cercor/bhu208

Abstract

Cognitive control (CC) and working memory (WM) are concurrently necessary for adaptive human behavior. These processes are thought to rely on similar neural mechanisms, yet little is known of the potential competitive or cooperative brain dynamics that support their concurrent engagement during complex behavioral tasks. Here, statistical interactions (synergy/competition) and dependencies (correlations) in brain function related to CC and WM were measured using functional magnetic resonance imaging. Twenty-five healthy adults performed a novel factorial cognitive paradigm, in which a 2-back verbal WM task was combined with the multisource interference task. Overlapping main effects in neural..

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University of Melbourne Researchers

Ben Harrison Author

Christos Pantelis Author

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Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

This study was supported by funding from the Australian National Health and Medical Research Council (project grant 1008921; program grant 566529; Clinical Career Development Fellowship 628509 to B.J.H.; Senior Principal Research Fellowship 628386 to C.P.; and Senior Research Fellowship 1021973 to M.Y.).